Table 1 Inclusion and exclusion criteria by screen
From: Study protocol: exercise training for treating major depressive disorder in multiple sclerosis
Inclusion criteria | Exclusion criteria |
|---|---|
Screen 1: First Level Criteria | |
 Physician-confirmed diagnosis of multiple sclerosis | High risk for contraindications of possible injury or death when undertaking strenuous or maximal exercise using the Physical Activity Readiness Questionnaire [25] |
 Relapse and steroid free in the past 30 days | Severe cognitive impairment based on Modified Telephone Interview for Cognitive Status score of less than 18 [26] |
 Internet and email access | Current high suicidal risk based on the Columbia-Suicide Severity Rating Scale screening version-recent [27] |
 Willingness to complete the testing and questionnaires, wear the accelerometer, undergo randomization, and engage in exercise training |  |
 Insufficient physical activity based on a Health Contribution Score of less than 14 units from the Godin Leisure-Time Exercise Questionnaire [28] |  |
 Ability to ambulate without assistance and Patient-Determined Disease Steps score between 0 and 2 (i.e., mild ambulatory disability) [29] |  |
 Age between 18 and 64 years |  |
 English as a primary language |  |
 Not pregnant and/or nursing |  |
 Presence of mild or more severe depressive symptoms based on Beck Depression Inventory – Fast Screen score of 4 or greater [30, 31] |  |
Screen 2: Second Level Criteria | |
 Major Depressive Disorder based on the MINI International Neuropsychiatric Interview [32] | Other severe mental illness (obsessive–compulsive disorder, schizophrenia, bipolar or other psychotic disorders, or recent or current addiction) as indicated by the MINI [32] |